Aging and Health, News and Research — By on December 8, 2010 9:48 pm

Chinese Mushroom Improves Youthful Genetic Expression
PROVO, Utah, October 7, 2010 /PRNewswire/ — New research from Nu Skin Enterprises, Inc. (NYSE:NUS) and its research partner LifeGen Technologies reveals specific anti-aging properties of Cordyceps sinensis (Cs-4), a mushroom traditionally believed to be an anti-aging herb in China. One investigation demonstrates Cs-4’s ability to combat age-related changes in gene expression in muscle and brain tissue. Two additional laboratory studies identify Cs-4’s positive impact on healthy lifespan due to overall positive benefits on energy metabolism, fatigue and endurance, as identified in previous studies.
“We’re making great breakthroughs in gene expression science that have application in the fields of health and longevity,” said Joe Chang, Ph.D., Nu Skin chief scientific officer and executive vice president of product development. “These studies with our research partner LifeGen Technologies help validate the critical role gene expression modulation plays in the aging process. We believe that the future of anti-aging is in developing consumer solutions that support youthful gene expression.”
“Because one of the earliest manifestations of human aging is a decline in vitality that begins as early as 30 years of age, we are targeting youth gene clusters that affect cellular mitochondria – the energy factories of the cells. Ingredients such as Cordyceps are shown to reset these genes to behave in a more youthful expression pattern,” continued Chang.
Steve Wood, Ph.D., R.D., director of global research for Nu Skin’s nutritional supplement brand, Pharmanex, presented research generated through Nu Skin’s partnership with LifeGen Technologies at the Biology of Aging Gordon Research Conference in Les Diablerets, Switzerland in August. The research reported effects of Cs-4 supplementation on the expression of genes in mice related to mitochondrial aging in skeletal muscle and brain tissue. Key conclusions presented at the conference include:
•The identification of age-associated nuclear gene expression related to mitochondria in muscle and brain tissue;
•Cs-4 opposed the age-related changes of expression in several of those genes; and
•Cs-4 opposed the effects of aging in multiple biochemical pathways (identified with gene ontology pathway analysis).

Angela Mastaloudis, Ph.D., senior scientist for Nu Skin’s nutritional supplement brand, Pharmanex, presented two studies at the elite Oxygen Club of California 2010 World Congress and received the prestigious DSM Nutraceutical Research Award. Josh Zhu, Ph.D., M.D., senior director for Pharmanex research and development at Nu Skin, was the lead scientist on the research. Conclusions of the three-year lifespan and antioxidant laboratory studies found that:
•Cs-4 extended the maximal and average lifespan of the population studied; and
•Cs-4 supplementation significantly improved antioxidant protection and reduced oxidative damage caused by an oxidative stressor.

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